![]() ![]() A broad range of mechanisms (with a final common pathway) appear to be involved. Severe/fatal cases of COVID-19 are associated with immune hyperactivation and excessive cytokine release, leading to multiorgan failure. Normally, these enable SARS-CoV-2 coronavirus particles to enter host cells, but therapeutically, inoculation triggers humoral (antibody-mediated) acquired immunity. In the case of COVID-19, inert spike (S) antigen proteins are produced. MRNA vaccines effect coded protein production in the recipient’s body. Being an mRNA vaccine, mass production is cheaper and more straightforward than with other vaccine formulations. Their vaccine candidate was more than 90% effective in preventing COVID-19 infection in participants without prior infection. ![]() ![]() Pfizer/BioNTech's recent announcement, therefore, is encouraging. Mass vaccination offers the best exit strategy from the COVID-19 pandemic. ![]()
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